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IVDD and PEMF
This post examines the claim that PEMF is a good treatment for intervertebral disc disease. Will a static magnetic field work or is it some sort of Faraday’s Induction getting charged particles to move? An extensive Background Education is presented to give the reader a visual of how stagnant and crowded matrices are in…
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PEMF and complex II
succinate dehydrogenase (SDH: SDHA-D), is made up of four protein subunits along with iron-sulfur (FeS) centers. Complex Portal links t the Swiss site UniProt.org. UniPort annotates the amino acid sites of proteins that interact with substrates and cofactors. Toda and coworkers 23023 investigated the effect of optimized extremely low frequency weak magnetic fields (Opti-ELF-WMF)…
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Leucine and niacin interactions
Leucine and niacin/ nicotinic acid (NA) seem to interact with each other to promote fat metabolism. B6 might also have synergistic interaction with leucine. The leucine/NA combination is also found in dietary supplements marketed by NuBio, which initiated this exploration that led us to NuSirt exploration. NuBio to NuTert A request was made to…
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PIKfyve regulation
PIKfyve may be phosphorylated on a number of different, some of which have a regulatory function. This post starts with a quick overview of PIKfyve interacting with the chaperone Vac14 that also binds the phosphatase Fig4. Regulation of PIKfyve is way more complicated that this. One of many phosphorylation sites was chosen for closer…
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TREK1
TREK1 is a voltage gated potassium channel that, when tethered to magnetic beads, is gated by low frequency PEMF. Could the mechanics of volume changes gate TREK1 in adrenal granulosa cells. We do not know. These cells produce cortisol when depolarized. The possibility is intriguing that PEMF opening of TREK1 channels and subsequent hyperpolarization…