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Presenillin and CIC7
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Presenillin, often referred to by its gene name PSEN1, is a subunit in the gamma secretase complex, which cleaves integral membrane proteins. This image was obtained from the UniProt link. The UniProt and Go annotations categorize PSEN1 as a mult-pass membrane protein found in all stages of endosomes,axon projections, and the synapse. The structure…
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Skeletal Muscle Autophagy
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Cleaning up damaged mitochondria is a key function of lysosomes. Skeletal muscle is particularly prone to damage to mitochondria that puts a strain on autophagy such that the lysosome portion of phagosomes needs to be blebbed off and recycled in an alternative pathway. The PIP that regulates CIC7 is phosphorylated on positions [3,5] not…
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CIC7 structure
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A very nice cryoelectron microscope image came out of the Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States. Richard K Hite was the corresponding author. These authors used a technique called Cryo Electron Microscopy to visualize CIC7 in actual membranes. [1]
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CLCN7 and the choroid plexus
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This post attempts to cover two publications of the Cl C7 exchanger in the choroid plexis of the brain. Links are given for figures that might be copyrighted. The intent is to provide an explanation as to what is going on in the open access journal articles.