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TREK1
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TREK1 is a voltage gated potassium channel that, when tethered to magnetic beads, is gated by low frequency PEMF. Could the mechanics of volume changes gate TREK1 in adrenal granulosa cells. We do not know. These cells produce cortisol when depolarized. The possibility is intriguing that PEMF opening of TREK1 channels and subsequent hyperpolarization…
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Honokiol and Sirt3
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A 2022 publication suggested that honokiol is effective in ameliorating cognitive impairment and mitochondrial dysfunction in a rodent and cell culture models of Alzheimer’s Disease. [1] Activation of sirtuin 3, Sirt3, was the proposed mechanism.
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Propionate and Mitochondria
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propionic acid is thought to play a role in autism. This post explores a publication that suggests that maleic acid, a metabolite of propionic acid, is the real mitochondria poison.
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Propionic Acid,Mitophagy, L-serine
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It would seem that dentritic spines have their own supply of mitochondria to produce ATP for all of the work they do. [1] More stimulation of dentritic spines leads to more mitochondria. The Li publication has some excellent images that will not be reproduced in this post. The featured image is a compilation of…
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PSEN1 and mitophagy
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This post is background information on a post describing the role of the role of PSEN1 in assembly of CIC7 in the lysosome and the mitophagy of dysfunctional mitochondria in Alzheimer’s Disease. This concept has relevance to all neurodegernative diseases in which mitochondria become damaged and need to be removed. The Martín-Maestro study is…