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Ozone Therapy
The usually objective Wikipedia online encyclopedia had an author that declared ozone therapy “pure quackary.” This post will explore the interaction between ozone therapy and the Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) transcription factor. The Wikipedia author failed to understand fundamentals of how low levels of a toxin can be protective. As the…
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Honokiol and Sirt3
A 2022 publication suggested that honokiol is effective in ameliorating cognitive impairment and mitochondrial dysfunction in a rodent and cell culture models of Alzheimer’s Disease. [1] Activation of sirtuin 3, Sirt3, was the proposed mechanism.
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Propionate and Mitochondria
propionic acid is thought to play a role in autism. This post explores a publication that suggests that maleic acid, a metabolite of propionic acid, is the real mitochondria poison.
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Propionic Acid,Mitophagy, L-serine
It would seem that dentritic spines have their own supply of mitochondria to produce ATP for all of the work they do. [1] More stimulation of dentritic spines leads to more mitochondria. The Li publication has some excellent images that will not be reproduced in this post. The featured image is a compilation of…
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PSEN1 and mitophagy
This post is background information on a post describing the role of the role of PSEN1 in assembly of CIC7 in the lysosome and the mitophagy of dysfunctional mitochondria in Alzheimer’s Disease. This concept has relevance to all neurodegernative diseases in which mitochondria become damaged and need to be removed. The Martín-Maestro study is…