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light and soluble guanylyl cyclase
What happens when to a molecule when it absorbs visible light? A 1999 Scientific American post explored the question of why a brick wall heats up when it absorbs light. Two explanations were given to this seemingly simple lay question: What happens when light strikes an object? Possibility #4 is particularly intriguing because the rate of…
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Leucine and niacin interactions
Leucine and niacin/ nicotinic acid (NA) seem to interact with each other to promote fat metabolism. B6 might also have synergistic interaction with leucine. The leucine/NA combination is also found in dietary supplements marketed by NuBio, which initiated this exploration that led us to NuSirt exploration. NuBio to NuTert A request was made to…
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Vps34
This post was initiated by a request to take a quick look at a review on the catalytic subunit of the class III phosphoatidylinositol 3-kinase catalytic subunit called vps34 in yeast. [1] The mammalian homolog is coded for by the PIK3c3 gene.
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PIKfyve regulation
PIKfyve may be phosphorylated on a number of different, some of which have a regulatory function. This post starts with a quick overview of PIKfyve interacting with the chaperone Vac14 that also binds the phosphatase Fig4. Regulation of PIKfyve is way more complicated that this. One of many phosphorylation sites was chosen for closer…
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TREK1
TREK1 is a voltage gated potassium channel that, when tethered to magnetic beads, is gated by low frequency PEMF. Could the mechanics of volume changes gate TREK1 in adrenal granulosa cells. We do not know. These cells produce cortisol when depolarized. The possibility is intriguing that PEMF opening of TREK1 channels and subsequent hyperpolarization…