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TRPC1 and PEMF
This post takes the model of Franco-Obregon 2023 that the QuantumTx brand of PEMF gates calcium currents of the transient receptor potential (TRP) family member TRPC1 by way of producing reactive oxygen species that modify the TRPC1 channel. There are some cysteines near some regulatory phosphorylation sites, calcium calmodulin binding sites, and ankyrin repeats,…
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Ozone Therapy
This post explores the interaction between ozone therapy and the Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) transcription factor. Ozone might react with thiols in a protein called Keap1 that targets the transcription factor Nrf2 for degradation. Nrf2 is responsible for transcription of genes whose proteins code for enzymes that protect against oxidative stress.…
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Voltage gated ClC7 in the choroid plexus
Mutations in the CLCN7 gene that codes for a “voltage dependent” Cl- channel ClC7 cause a lysosomal storage disorder associated with osteopetrosis, hypopigmentation, and other problems. Years back I found myself exploring the role this Cl- channel in acid/base homeostasis of the choroid plexus, the membrane that separates the blood and the cerebral spinal…